Read an excerpt from Dr. John Flucke’s article in the December 2021 issue of Dental Products Report where he discusses Nobio’s new technology infinix and what it can do for you. Click on the PDF download to read more.
Kadima, Israel; September 9, 2021 — Nobio Ltd., inventor of the only FDA cleared antibacterial composites shown to significantly reduce demineralization, has been selected as a 2021 Cellerant Best of Class Technology Award recipient. The company’s infinix line of advanced restorative materials is a second time award winner, having also been honored in 2020.
“During what is once again proving to be a very challenging year for the dental industry, each of these extraordinary companies and their award winning technologies have earned the right to celebrate,” said Dr. Lou Shuman, CEO of Cellerant and founder of the Best of Class Technology Awards. “I strongly encourage dentists to take the opportunity to engage with these companies and their innovations both virtually and in person.”
“We are gratified that the Best of Class panel continues to recognize the clinical importance of infinix,” said Prof. Ervin Weiss, DMD, Nobio’s co-founder, and Dean Emeritus of the School of Dentistry of Tel-Aviv University. “The goal is providing long lasting bacterial inhibition at the restorative margins, preventing demineralization associated with the decay process, and ultimately reducing restoration failure due to secondary caries.”
“There is so much innovation information to process each year,” said John Flucke, DDS, Best of Class panel member. Flucke continues, “We do our best to comb the industry and identify products with the greatest potential impact. We hope to help our colleagues, who are already juggling patient care, staff concerns, and so much else, to more easily decide what makes sense in their practices.”
The 2021 Cellerant Best of Class Technology Award is selected by a panel of the most prominent technology leaders in dentistry: Paul Feuerstein, DMD, Editor in Chief for Dentistry Today, John Flucke, DDS, technology editor for Dental Products Report, Marty Jablow, DMD, known as America’s technology coach, Pamela Maragliano-Muniz, DMD, editor-in-chief for Dental Economics, Chris Salierno, DDS, chief dental officer for Tend, and Lou Shuman, DMD, CAGS, founder and creator of the Best of Class Technology Award.
“The infinix family of restoratives is the first use case of a fundamental technology platform, that we see as applicable to a wide range of dental products,” said Ronen Raz, Nobio Chief Operation Officer. The infinix line includes, bulk-fil, universal, and flowable composites, as well as a universal light-cured bonding system, all incorporating Nobio’s patented QASi™ antimicrobial particle technology. “We appreciate what this recognition from this distinguished panel of thought leading clinicians says not only about infinix, but also about the broader promise of the Nobio platform.”
About Nobio
Nobio is a material sciences company that redefines the field of antimicrobial products and solutions with its long-lasting, safe, and highly active novel particle technology. Nobio developed and is commercializing Infinix, the first line of dental materials with its revolutionary antimicrobial technology to address the main causes of dental treatment failure and tooth loss. Nobio is also working with leading medical, dental, consumer, and industrial manufacturers to bring long-lasting antimicrobial properties to a wide range of products and applications. For more information, visit www.nobio.com
About the Cellerant Best of Class Technology Award
Since the inaugural presentation in 2009, the Best of Class Technology Awards have grown to occupy a unique space in dentistry by creating awareness in the community of manufacturers that are driving the discussion as to how practices will operate now and in the future.
The selection process relies on an expert panel of dentists recognized as thought leaders and educators. It includes Dr. Paul Feuerstein, Dr. John Flucke, Dr. Marty Jablow, Dr. Pamela Maragliano-Muniz, Dr. Chris Salierno, and Dr. Lou Shuman. Over the course of each year, the panel members seek out and conduct research on potentially practice-changing technologies, with deliberations on nominees and final voting taking place in February. Panelists are precluded from voting in any category where they have consulting relationships. The entire selection process is conducted and managed on a not-for-profit basis.
For more information on the Cellerant Best of Class Awards and the 2021 Award Winners, go to www.cellerantconsulting.com/best-of-class.
About Cellerant Consulting Group
Founded and led by CEO Dr. Lou Shuman, DMD, CAGS, Cellerant provides strategic dental market insights, clinical expertise, implementation resources and support to accelerate growth for client dental companies. Cellerant services include new concept incubation, clinical product evaluation, product development, continuing education program development and CE sponsorship, strategic branding and marketing, online marketing, content marketing and dental media relations management. As an orthodontist and former owner of a 10-doctor multi-specialty private group practice, Dr. Shuman guides clients to offer products that engage dental customers and provide sustained differentiation. Cellerant operates under a unique model that merges leading voices in clinical product evaluation and strategic partner companies to provide a menu of services from one easily accessible network.
Nobio Press Contact
Hanna Elbaz
hanna@nobio.com
www.nobio.com
Cellerant Press Contact
Stephanie Schulze
Executive Consultant
Cellerant Consulting Group
Phone: 800-884-5707 x 111
stephanie@cellerantconsulting.com
www.cellerantconsulting.com
This in situ clinical study showed that composites with QASi antibacterial particles significantly reduced demineralization in enamel adjacent to a 38-μm gap over a 4-week period in comparison to a conventional composite.
Read MoreNobio’s Antibacterial Composites Receive FDA 510(k) Clearance for Addressing a Key Process in Tooth Decay
Clinical data show that Infinix composites significantly reduce tooth demineralization.
Kadima, Israel – September 8, 2020 -- Nobio Ltd. today announced it has received an additional FDA 510(k) clearance for the company’s Infinix™ family of dental composites. Clinical data supporting the company’s submission to the FDA demonstrated that Nobio Infinix antibacterial composites significantly reduce tooth demineralization, which is part of the caries-formation (tooth decay) process. Read more at FDAnews.com.
“The data further validates our technology which promises a breakthrough in restorative dentistry improving outcomes for dentists and their patients” said Yoram Ashery, Nobio CEO. Nobio’s Infinix composites incorporate its patented QASiTM particle technology, which has shown long lasting inhibition of bacterial growth at the margins of composite fillings. “Infinix gives dentists a new tool to fight recurrent caries which is the main cause of restoration failure” said Ashery.
Tooth decay is a process, where bacteria generate acids that dissolve teeth by causing demineralization (tooth mineral loss), which leads to cavitated lesions (caries). Recurrent caries, tooth decay that occurs under existing fillings, crowns, or onlays, is a major cause of premature restoration failure.
A clinical study was performed at the University of California, San Francisco (UCSF) to assess Infinix’ s antibacterial activity in slowing and reducing demineralization. This study, completed in March, was led by principal investigator Peter Rechmann, DMD, PhD, professor and director of the Clinical Sciences Research Group at the UCSF School of Dentistry, and President of the American Academy of Cariology. “Our study showed that mineral loss in teeth adjacent to Infinix composites was two-thirds less than for the standard composite material, indicating the potential for less recurrent decay, longer-lasting restorations and less natural tooth loss”, said Dr. Rechmann.
Prof. Ervin Weiss, DMD, Nobio’s CTO and co-founder, and Dean Emeritus of the School of Dentistry of Tel-Aviv University, added, “We believe Infinix is a major advancement for dentistry that will reduce the likelihood of restoration failures due to secondary caries with its associated discomfort and costs.”
Nobio plans to initiate commercial sales of its Infinix product line by the end of this year. Dentists interested in trying Infinix composites can reserve a free Starter Kit at www.Infinix.com.
About Nobio
Nobio is a material sciences company that redefines the field of antimicrobial products and solutions with its long-lasting, safe, and highly active novel particle technology. Nobio developed and is commercializing Infinix, the first line of dental materials with its revolutionary antimicrobial technology to address the main causes of dental treatment failure and tooth loss. Nobio is also working with leading medical, dental, consumer, and industrial manufacturers to bring long-lasting antimicrobial properties to a wide range of products and applications. For more information, visit www.nobio.com
UC Disclaimer
The information stated above was prepared by Nobio to report on research conducted on its product and reflects solely the opinion of Nobio. Nothing in this statement shall be construed to imply any support or endorsement of Nobio, or any of its products, by The Regents of the University of California, its officers, agents, and employees.
Contact
Hanna Elbaz
(844) INFINIX
hanna@nobio.com
Scott Maier, UCSF
(415) 463-0110
scott.maier@ucsf.edu
Nobio’s Infinix Antibacterial Composites Recognized as a 2020 Cellerant Best of Class Technology Award Winner
The Award is selected by a panel of the most prominent technology leaders in dentistry.
Kadima, Israel – September 3, 2020 -- Nobio Ltd. today announced that its Infinix family of composites has been selected as a 2020 Cellerant Best of Class Technology Award recipient in the emerging technology category. The Best of Class “Emerging” awards recognize innovative technologies that either define new product categories altogether or stand to challenge established category leadership. The “Emerging” designation is intended to alert the dental community to promising new technologies or companies that have the potential to greatly impact the standard of care in dentistry.
“Announcing the award winners is especially meaningful this year,” said Dr. Lou Shuman, CEO of Cellerant and founder of the Best of Class Technology Awards. "The Chicago Midwinter, where the Best of Class Panel selected the award winners, was really the last in person event for the dental community in 2020. Dentists and their staffs, as well as these companies have overcome many unbelievable challenges since then. So, it’s exciting and uplifting to change the narrative for a moment by recognizing these deserving award winners and sharing these amazing technologies with our colleagues.”
"The idea is simple, while the science is pure genius”, commented Dr. John Flucke, Best of Class panel member, Technology Editor and Chief Dental Editor of Dental Products Report. “Nobio has developed a chemical with antibacterial properties and incorporated it into Infinix composite. Most composite restorations last just 5 to 7 years due to recurrent caries at the restoration/tooth interface. Infinix solves that problem by basically killing any bacteria that comes in contact with the restoration.”
Watch the Infinix award winning announcement here and the whole 2020 Best of Class Award ceremony on Dental Products Report.
About the Cellerant Best of Class Technology Award
Since the inaugural presentation in 2009, the Best of Class Technology Awards have grown to occupy a unique space in dentistry by creating awareness to the dental community what technologies and products of the thousands available can truly impact how practices will operate now and in the future.
The selection process relies on an expert panel of dentists recognized as thought leaders and educators. It includes, Dr. John Flucke, Dr. Marty Jablow, Dr. Paul Feuerstein, Dr. Chris Salierno, Dr. Pamela Maragliano- Muniz, and Dr. Lou Shuman. Over the course of each year, the panel members seek out and conduct research on potentially practice-changing technologies, with deliberations on nominees and final voting taking place in February. Panelists are precluded from voting in any category where they have consulting relationships. The entire selection process is conducted and managed on a not-for-profit basis.
About Cellerant Consulting Group
Founded and led by CEO Dr. Lou Shuman, DMD, CAGS, Cellerant provides strategic dental market insights, clinical expertise, implementation resources and support to accelerate growth for client dental companies. Cellerant services include new concept incubation, clinical product evaluation, product development, continuing education program development and CE sponsorship, strategic branding and marketing, online marketing, content marketing and dental media relations management. As an orthodontist and former owner of a 10- doctor multi-specialty private group practice, Dr. Shuman guides clients to offer products that engage dental customers and provide sustained differentiation. Cellerant operates under a unique model that merges leading voices in clinical product evaluation and strategic partner companies to provide a menu of services from one easily accessible network.
About Nobio
Nobio is a material sciences company that redefines the field of antimicrobial products and solutions with its long-lasting, safe, and highly active novel particle technology. Nobio developed and is commercializing Infinix, the first line of dental materials with its revolutionary antimicrobial technology to address the main causes of dental treatment failure and tooth loss. Nobio is also working with leading medical, dental, consumer, and industrial manufacturers to bring long-lasting antimicrobial properties to a wide range of products and applications. For more information, visit www.nobio.com
Contact
Hanna Elbaz
(844) INFINIX
hanna@nobio.com
Thais Carter, Senior Executive Consultant Cellerant Consulting Group
800-884-5707 x107
thais@cellerantconsulting.com
Airing on Fox Business Network on Sunday, February 16, 2020 at 5:30 pm EST.
Read MoreFDA Clears Infinix™ Antibacterial Universal Bond
Read MoreSecondary caries is a significant cause of premature restoration failure and is a concern for both patients and dentists. That’s why I was so excited to hear about a long-lasting technology that inhibits bacterial growth and biofilm formation without the use of chemicals and without affecting the natural flora of the mouth. I wanted to learn all about it, so I sat down with the founder of Nobio, Dr. Ervin Weiss, and the company’s CEO, Yoram Ashery, to find out more.
Read MoreNot since the development of composites in the 1960s and the introduction of CAD/CAM in the 1980s has there been such an exciting time of innovation in dentistry. Researchers, manufacturers, scientists and practitioners are welcoming new and emerging technologies, from 3D printing and self-healing teeth to non-chemical disinfectants and digital scanning — all of which have the potential to transform in meaningful ways how dentistry is practiced.
Read MoreAtar-Froyman L, Sharon A, Weiss EI, Houri-Haddad Y, Kesler-Shvero D, Domb AJ, Pilo R, Beyth N. Biomaterials. 2015;46:141–8.
Shvero DK, et al. Characterisation of the antibacterial effect of polyethyleneimine nanoparticles in relation to particle distribution in resin composite. Journal of Dentistry (2014)
PLOS ONE, November 2013, Volume 8, Issue 11, e78586
Quintessence International. 2013
2012 International Endodontic Journal.
Beyth N, Yudovin-Farber I, Perez-Davidi M, Domb AJ, Weiss EI. PNAS. 2010; December 21, 2010 107;51:22038–22043.
Click here for PNAS Supporting Information (Beyth et al. 10.1073/pnas.1010341107)
Abstract
Incorporation of cross-linked quaternary ammonium polyethylenimine (QPEI) nanoparticles in dental resin composite has a long-lasting and wide antimicrobial effect with no measured impact on biocompatibility in vitro. We hypothesized that QPEI nanoparticles incorporated into a resin composite have a potent antibacterial effect in vivo and that this stress condition triggers a suicide module in the bacterial biofilm. Ten volunteers wore a removable acrylic appliance, in which two control resin composite specimens and two resin composite specimens incorporating 1% wt/wt QPEI nanoparticles were inserted to allow the buildup of intraoral biofilms. After 4 h, the specimens were removed and tested for bacterial vitality and biofilm thickness, using confocal laser scanning microscopy. The vitality rate in specimens incorporating QPEI was reduced by > 50% (p < 0.00001), whereas biofilm thickness was increased (p < 0.05). The ability of the biofilm supernatant to restore bacterial death was tested in vitro. The in vitro tests showed a 70% decrease in viable bacteria (p < 0.05). Biofilm morphological differences were also observed in the scanning electron microscope micrographs of the resin composite versus the resin composite incorporating QPEI. These results strongly suggest that QPEI nanoparticles incorporated at a low concentration in resin composite exert a significant in vivo antibiofilm activity and exhibit a potent broad spectrum antibacterial activity against salivary bacteria. Click here to read full article.
Beyth N, Yudovin-Fearber I, Domb AJ, Weiss EI. Quintessence International. 2010;41(10):827–35.
Quintessence International. 2009
JOE — Volume 34, Number 6, June 2008
Esti Davidovich, Ervin Weiss, Anna B. Fuks and Nurit Beyth J Am Dent Assoc 2007;138;1347-1352
dental materials 24 (2008) 732–736
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